Engaging videos that delve into the science of living much longer
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I took NMN every day and this is what happened
I took NMN every day and this happened
In this video, the creator talks about his personal experience after taking NMN every day for 60 days. He says the first thing he noticed was more energy, but not in a jittery way like with caffeine. He describes it more as a strong alertness and a feeling of being more awake and present.
As a result, he had a bit of trouble sleeping during the first few days. That effect seemed to wear off after that, after which he felt his body became more accustomed to the supplement. The extra alertness remained present, but was less extreme than at the beginning.
Later he noticed other changes. For instance, he mentions a skin blemish that disappeared and did not return quickly, something that struck him because that used to happen previously. He also mentions that his sister said he looked younger and seemed to have fewer wrinkles.
At the same time, he remains cautious about this. He says himself that he cannot prove with certainty that this is solely due to NMN, because, for example, he has also been using collagen for a long time. The tone of the video is therefore primarily: striking personal experiences, but no hard evidence.
- Used NMN daily for 60 days
- First effect: more energy and increased alertness
- Initially, sleeping worse temporarily
- Subsequent potential exterior alterations noticed
- The creator remains cautious and makes no claims to scientific evidence
NMN supplements versus NAD⁺ infusion therapy: what is the right choice for you?
NMN vs NAD+ IV: which one really works better?
This video explains the difference between NMN supplements and NAD+ IV therapy. Both are intended to increase NAD+ levels in your body, a substance that is essential for energy production, repair, and ageing processes.
NMN is a precursor to NAD+ and is taken via supplements. The body then converts NMN into NAD+ itself. This makes it a practical and accessible way to support your NAD+ levels daily, although it takes longer to notice an effect.
NAD+ IV therapy works more directly because NAD+ is delivered straight into the bloodstream via a drip. As a result, effects can be noticeable more quickly, but it is more expensive, more time-consuming and must be performed medically.
The video emphasises that the choice depends mainly on your goal. For long-term use and convenience, supplements make sense, whereas IV therapy is more focused on rapid results or specific situations. At the same time, it is noted that scientific evidence is still limited and results vary per person.
- Both increase NAD+, which is important for energy and cell repair
- NMN = precursor, slow but practical and affordable
- NAD+ IV = direct effect, but expensive and less practical
- Choice depends on purpose: daily use vs quick boost
- Evidence in humans is still limited, results vary
Essentials: The biology of slowing down and reversing ageing | Dr. David Sinclair
The biology of ageing and how to slow it down
In this video, Dr David Sinclair explains that ageing is not just wear and tear, but primarily a loss of information in your cells. He describes how the epigenome – which determines which genes are switched on or off – gradually becomes dysregulated, causing cells to function less well.
According to him, aging is therefore essentially a treatable process. If you address the underlying mechanisms, you can not only slow down old age, but potentially also reverse certain aspects. This idea is also seen as a new way of thinking about disease: many conditions are actually consequences of aging itself.
The video emphasises that lifestyle plays a major role in this. Things such as fasting, exercise and exposure to mild stress (such as cold or hunger) activate the body’s repair mechanisms. These processes switch on so-called “longevity genes”, which aid in the repair and maintenance of cells.
In addition, substances that increase NAD+, such as NMN, are being looked at because they are involved in energy production and cell repair. Nevertheless, it is made clear that many of these interventions are still in development and that the evidence in humans is still limited.
- According to Sinclair, ageing is primarily a loss of cellular information
- The epigenome plays a central role in this process
- Ageing is seen as a treatable process
- Lifestyle (fasting, exercise, stress triggers) activates repair mechanisms
- NAD+ and supplements such as NMN may potentially support
- Evidence in humans is still developing
Have we found the fountain of youth yet? – The Global Story, BBC World Service
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Summary: The search for the 'Fountain of Eternity'
Scientists are increasingly understanding how we age at a cellular level. Dr Andrew Steele explains that ageing is not a single process, but an accumulation of various forms of biological damage, also known as the hallmarks of ageing. Instead of focusing solely on external characteristics such as wrinkles, science is targeting the prevention of age-related diseases such as cancer and dementia by addressing the root cause — biological ageing itself.
Experiments are being conducted with drugs such as senolytics and rapamycin, which have already been successful in animal tests at extending healthspan. The ultimate goal is not only to make people live longer (lifespan), but above all to extend the period in which we are healthy and vital (healthspan). A surprising tip from Dr Steele: good oral hygiene helps prevent chronic inflammation, which is essential for a healthier ageing process.
Explanation of difficult terms
- Longevity: The science that investigates not only how we can live longer, but above all how we can remain healthy for longer.
- Lifespan vs. Healthspan: Lifespan is the total number of years you live. Healthspan is the number of years you live in good health, without serious chronic diseases.
- Epigenetic clock: A test (often using blood or saliva) that looks at markers on your DNA to measure your biological age, which may differ from your chronological age in years.
- Senescent cells: 'Aged' cells that have stopped dividing but do not die. They accumulate in the body and secrete substances that cause inflammation and damage to healthy cells.
- Senolytics: A class of drugs specifically designed to clear out senescent cells.
- Cellular reprogramming: A technique whereby cells are genetically 'reset' to a younger state, similar to how stem cells work.
- Chronic inflammation: A mild, constant inflammation in the body that increases as we get older and forms the basis for many ailments of ageing.
Reversing ageing: Dr. David Sinclair on NMN and anti-ageing supplements (including their side effects)
Summary: Do anti-ageing supplements like NMN really work?
In this video, Dr David Sinclair explains how supplements such as NMN and other NAD+ boosters may influence ageing. He describes that a key hallmark of ageing is the decline of NAD+, a substance that is essential for energy production, DNA repair and the proper functioning of cells. By increasing this level, researchers hope to slow down ageing processes.
The video makes it clear that there are promising results from animal studies, in which increasing NAD+ leads to better cell function, more energy and potentially a longer healthspan. At the same time, Sinclair emphasises that human evidence is still limited. There are indications that it may be safe and have benefits, but hard conclusions are still lacking.
In addition, the hype surrounding supplements is addressed. Although science is developing rapidly, the video warns that many claims are premature. Supplements can play a role, but are not a cure-all. The foundation of healthy ageing remains lifestyle, such as nutrition, exercise and avoiding damage to the body.
Explanation of difficult terms
- NAD+: An essential substance in cells involved in energy production and repair processes.
- NMN (Nicotinamide Mononucleotide): A precursor to NAD+ used as a supplement to increase NAD+ levels.
- DNA repair: Processes in the body that repair damaged DNA.
- Mitochondria: The powerhouses of the cell that rely on NAD+.
- Supplements: Additional substances (such as pills or powders) intended to support health.
- Animal testing: Scientific research that is first tested on animals before it is applied to humans.
- Healthspan: The number of years you live in good health and vitality.
Dr Warner discusses the benefits of NMN and how it can improve your lifespan – Well Theory
Summary: NMN and healthy ageing according to Dr Warner
In this video, Dr Meredith Warner explains how supplements such as NMN (nicotinamide mononucleotide) may help contribute to healthier ageing. She focuses mainly on the importance of NAD+, a substance in the body that is essential for energy, cell repair and proper cell functioning. As we age, the level of NAD+ declines, which can lead to reduced energy and more age-related problems.
NMN is used by the body to produce NAD+. According to Dr Warner, increasing NAD+ can help cells function better and potentially slow down the ageing process. She discusses how this leads many people to experience more energy and feel more vital. The effect on muscle strength, recovery and general health is also examined.
At the same time, she emphasises that while the results are promising, scientific evidence in humans is still developing. Much of the knowledge comes from animal studies and smaller trials. Therefore, it is important to remain realistic: NMN can be supportive, but it is not a cure-all. A healthy lifestyle remains the foundation for ageing well.
Explanation of difficult terms
- NAD+: A substance in your body needed for energy production and cell repair. The amount decreases with age.
- NMN (nicotinamide mononucleotide): A substance that the body uses to produce NAD+ and is often used as a supplement.
- Cell repair: The process by which damaged cells are repaired to function healthily.
- Mitochondria: Parts of cells that produce energy and are therefore often called the ‘energy factories’ of the body.
- Ageing process: The gradual decline of functions in the body as we get older.
- Supplement: An addition to the diet, often in the form of pills or powder, intended to supplement certain substances.
A new era in longevity science: models of ageing, rapamycin research, biological clocks and more
Summary: The new phase of longevity science
The video shows that longevity science has entered a new phase in which aging is no longer merely described, but is increasingly being measured and influenced. Researchers are no longer looking at a single cause, but view aging as a network of processes that together make the body less resilient. Aging is thereby seen not only as damage, but primarily as the loss of the ability to recover and remain in balance.
An important part of this development is so-called biological clocks. These try to measure how “old” your body really is, independently of your chronological age. They use biomarkers such as blood values and DNA signals to make the ageing process visible. Although these clocks are promising, they are still under development and not yet fully reliable for individual use.
In addition, much attention is paid to drugs such as rapamycin, which influences the mTOR pathway in the body. This system plays an important role in growth, repair and ageing. In animal studies, rapamycin has shown life extension, and studies in humans are now underway to investigate whether this is also safe and effective. At the same time, caution remains necessary, as the correct dosage and long-term effects are not yet fully clear.
The video also emphasises that ageing can be modelled in different ways: as a gradual accumulation of damage, but also as an increasing probability of body systems failing. The future likely lies in combining insights from different models and enhancing the body's resilience, rather than tackling a single problem.
Finally, it becomes clear that many new interventions are in development, such as NAD+, AKG and other substances that support metabolism. Nevertheless, the most important message remains that we are still at the beginning: science is developing rapidly, but many applications are still experimental and require more research before they can be widely deployed.
Explanation of difficult terms
- Longevity: The science that focuses on living longer and, above all, staying healthy for longer.
- Biological clock: A measurement method that attempts to determine how old your body really is based on biomarkers.
- mTOR: An important regulatory system in cells that influences growth, energy use and ageing.
- Rapamycin: A medicine that inhibits the mTOR system and may potentially slow down ageing.
- Biomarkers: Measurable signals in the body, such as blood levels, that indicate something about health or ageing.
- Resilience: The ability of the body to recover after stress or damage.
- AKG (alpha-ketoglutarate): A substance involved in energy production and which may have an effect on ageing.
The breakthrough in life extension that is there for the taking Jay Luthar TEDxBoston
Summary: The breakthrough in longevity lies in our daily behaviour
The video makes it clear that the biggest breakthrough in longevity is not futuristic technology, but something that has long been known: our daily lifestyle. Instead of searching for a single miracle cure, Jay Luthar emphasises that health is primarily determined by consistent habits such as diet, exercise, sleep and stress management. These factors have a direct and powerful influence on how fast we age and how healthy we remain.
An important point is that modern medicine is primarily focused on treating disease, whereas real progress lies in prevention. By intervening earlier and investing in health before symptoms arise, many chronic diseases can be prevented. This requires a different way of thinking: not waiting until something goes wrong, but actively building a healthy body.
In addition, the video emphasises the importance of personal and continuous care. Health is not a snapshot, but a process that requires attention and guidance. Small improvements, applied consistently over a longer period of time, ultimately yield the greatest gains. The real “breakthrough” therefore lies not in a single discovery, but in the consistent application of what we already know.
Explanation of difficult terms
- Longevity: The science that focuses on living longer while also staying healthy for longer.
- Preventative medicine: An approach that focuses on preventing illnesses rather than treating them.
- Lifestyle: Daily habits such as diet, exercise, sleep and stress management that affect health.
- Chronic illnesses: Long-term conditions such as cardiovascular disease, diabetes and dementia.
- Healthspan: The number of years you live in good health, without serious illnesses.
- Consistency: The regular and long-term maintenance of healthy habits.
- Holistic approach: Viewing health as a whole, taking multiple factors into account together.
100-year-old nutrition professor: 7 keys to a long life | Dr. John Scharffenberg
Summary: 7 simple rules for a long and healthy life
In this video, Dr John Scharffenberg, a 100-year-old nutrition professor, shares his vision on longevity. His message is strikingly simple: a long and healthy life is not determined by genetics or expensive treatments, but primarily by daily lifestyle choices. According to him, most diseases of old age can be prevented by consistently avoiding risk factors.
The core of his story revolves around seven key habits. He emphasises the complete avoidance of smoking and alcohol, as these directly contribute to disease and premature mortality. In addition, diet plays a major role: he advocates a predominantly plant-based diet and the limitation of sugar and saturated fats. Physical exercise is also crucial, especially in middle age, where he believes it has the greatest impact on lifespan and health.
What makes this vision special is that it is not about complex theories, but about discipline and consistency. Small, daily choices — such as exercising, eating healthily and avoiding harmful habits — have, according to him, an enormous influence on the risk of heart disease, diabetes and other chronic conditions. His own life is proof of that.
Explanation of difficult terms
- Longevity: The science that focuses on living longer and, above all, staying healthy for longer.
- Plant-based diet: A dietary pattern based on vegetables, fruit, grains, nuts and seeds, with few or no animal products.
- Saturated fats: Types of fat that can increase the risk of cardiovascular disease.
- Chronic illnesses: Long-term conditions such as heart disease, diabetes and cancer.
- Intermittent fasting: An eating pattern where you alternate periods of eating with periods of not eating.
- Risk factors: Habits or circumstances that increase the likelihood of disease, such as smoking, poor diet or lack of exercise.
- Prevention: The avoidance of illness by making healthy choices before symptoms arise.
The real reasons for using nicotinamide adenine dinucleotide (NAD⁺)
The Real Reasons to Use NAD+
In this video, Dr Paul Anderson explains that NAD+ (Nicotinamide Adenine Dinucleotide) is a crucial coenzyme that acts as the active form of vitamin B3. It is essential for almost every process in our body, from energy production to DNA repair.
The most important function of NAD+ takes place in the mitochondria, the energy factories of our cells. Here, the molecule is responsible for initiating the chemical chain that produces ATP, the universal fuel for our body. Without sufficient NAD+, cells cannot generate energy efficiently, leading to fatigue and slow recovery after illness.
Besides energy, NAD+ plays a vital role as an enzymatic co-factor. It is involved in the production of neurotransmitters for healthy brain function, helps detoxify the body and supports the breakdown of histamine. It also helps regulate inflammatory responses in both the body and the brain.
Dr Anderson discusses various strategies for increasing NAD levels, ranging from basic nutrients to advanced supplements and medical interventions:
- Niacinamide: A stable and economical form of vitamin B3 that is ideal for long-term maintenance without side effects such as the 'niacin flush'.
- NMN (Nicotinamide Mononucleotide): An effective precursor that is taken orally and directly helps to increase cellular NAD levels.
- NR (Nicotinamide Riboside): The most potent oral form that generally provides the fastest increase in energy levels because it requires the fewest conversion steps in the body.
- Intravenous (IV) Therapy: The fastest method to replenish deficiencies, often used for chronic fatigue or complex recovery.
Although NAD support is very safe, the doctor warns against too high a dose all at once. This can lead to a feeling of overstimulation, similar to too much caffeine, which may manifest as heart palpitations or disturbed sleep. He therefore advises starting with a low dose and preferably taking it in the morning.
Never get the disease of Alzheimer’s Diseasethe NAD breakthrough
Never Again Alzheimer's: The NAD+ Breakthrough
In this video, Dr Nick Norwitz discusses a groundbreaking scientific publication that fundamentally changes the way we look at Alzheimer's disease. Instead of viewing Alzheimer's solely as an accumulation of amyloid plaques, this new research points out that it is primarily a problem of brain energy metabolism.
The central player in this process is NAD+ (Nicotinamide Adenine Dinucleotide). This molecule is essential for energy supply in every cell. The research shows that people with many amyloid plaques who nevertheless remain cognitively healthy have strikingly high NAD levels. NAD+ therefore acts as a 'resilience factor' that protects brain functions against the damage of the disease.
In animal models, increasing NAD levels led to spectacular results: it not only improved spatial memory and motor skills, but also reversed the pathological features of Alzheimer's. For example, the amount of toxic tau proteins decreased, the blood-brain barrier was restored, and inflammation in the brain was significantly reduced.
To naturally support your own NAD levels and protect your brain, Dr Norwitz provides the following action points:
- Physical exercise: Both cardio and strength training activate the enzyme NAMPT, the main pathway for recycling NAD+ in the body.
- Dietary interventions: Intermittent fasting and a ketogenic diet stimulate the production of NAD+ by bringing cells into a metabolic state that promotes its production.
- Reduce consumption: Chronic inflammation and oxidative stress deplete NAD+. Good sleep and a healthy diet help to conserve your reserves.
- Natural inhibitors: Substances such as quercetin (in onions and capers) and apigenin (in chamomile tea) inhibit enzymes that break down NAD+.
- Supplements: Precursors such as NMN or NR can directly help to increase levels, whilst substances like Lyso-DHA and micro-dosed lithium can offer additional protection.
The video's conclusion is hopeful: by focusing on the foundation of cellular energy, a new path emerges for the prevention and potentially even the reversal of Alzheimer's.
This supplement is the FASTEST way to boost NAD
The Fastest Way to Boost NAD+: NR vs NMN
This video explains why direct supplementation of NAD+ is ineffective and why specific precursors such as Nicotinamide Riboside (NR) are superior for increasing cellular NAD levels.
The biggest obstacle for NAD+ and its precursor NMN is the presence of a phosphate group. Cells cannot directly absorb molecules with phosphates. As a result, NAD+ and NMN must first be broken down into NR in the digestive tract or outside the cell before they can pass through the cell wall. Once inside the cell, NR is converted back into NMN and ultimately into NAD+.
NR (Nicotinamide Riboside) is described as the 'premium' precursor because it can enter the cell directly without first needing to be broken down. Furthermore, the pathway used by NR (via the enzyme NRK) is specifically activated during periods of metabolic stress, such as in heart failure or nerve damage. This makes NR more effective in situations where other forms of vitamin B3 fall short.
The key insights into the different forms of NAD boosters are:
- NAD+ Supplements: Oral NAD+ supplements are inefficient because the large molecule must be completely broken down into smaller particles such as NR before it can be used by the cells.
- NMN vs NR: Although NMN is often promoted as being 'one step closer' to NAD+, because of its phosphate group outside the cell it must first be converted into NR. NR is therefore the most direct pathway into the cell.
- Infusion therapy (IV): NAD infusions can be painful and provoke an immune response because NAD+ cannot enter the cells directly. There are now newer 'drip-grade' NR infusions that do not have these painful side effects and appear more effective in reaching various tissues.
- Safety and Quality: NR has been extensively tested for safety in human clinical trials. With over-the-counter NMN supplements, purity is often an issue; many products do not contain the amount stated on the label.
The conclusion is that Nicotinamide Riboside (NR) is currently the most reliable, clinically tested, and bioavailable method to quickly and effectively increase NAD levels in the body.
What you NEED to know about oral NAD supplements | You might be using them the wrong way
This supplement is the FASTEST way to boost NAD
What you need to know about oral NAD supplements
In this video, Dr Paul Anderson explains how NAD+ (Nicotinamide Adenine Dinucleotide) works as a crucial 'primer' for countless processes in our body. He draws a distinction here between mitochondrial functions (energy production) and non-mitochondrial functions, such as the production of neurotransmitters in the brain and enzymatic processes in the liver.
Because swallowing pure NAD+ is largely ineffective — the digestive system breaks down the molecule before it can reach the cells — the doctor discusses the most effective oral alternatives and how to use them optimally.
The main points from the video on supplementation are:
- Niacinamide (Vitamin B3): The most cost-effective way to support NAD production. However, it works slowly and is primarily suitable for long-term, subtle support of the baseline supply.
- Precursors (NR and NMN): Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are more direct precursors that are well absorbed by the gastrointestinal tract. NR is often considered the fastest method to experience a noticeable energy boost, sometimes within an hour.
- Optimal dosage: The need varies per person. Some people feel 'hypersensitive' or overstimulated (similar to too much caffeine) at a standard dose. In that case, the advice is to start lower or take the dose every other day.
- Combine with B-complex: Because NAD+ speeds up the metabolism, the body also consumes other B vitamins more quickly. It is therefore essential to always combine an NAD booster with a complete B complex to prevent deficiencies elsewhere.
- Supporting nutrients: Besides B vitamins, vitamin C and minerals (such as magnesium and trace elements like zinc and selenium) are also needed to keep pace with the accelerated enzymatic processes in the cells.
Dr Anderson emphasises that supplements should always be a complement to a nutrient-rich diet. Once energy levels have been restored and the underlying causes of fatigue have been addressed, many people can reduce the dosage of expensive precursors such as NR and switch to a maintenance dose of simpler niacinamide.
How to boost NAD levels to fight inflammation, improve recovery and slow down ageing
This supplement is the FASTEST way to boost NAD
Boosting NAD+ Levels for Inflammation, Recovery and Ageing
In this in-depth episode, Dr. Charles Brenner, an authority in the field of NAD biology and discoverer of Nicotinamide Riboside (NR) as a vitamin, discusses the crucial role of NAD coenzymes. He explains that NAD+ is not merely an 'anti-aging' buzzword, but forms the fundamental 'wiring' for the transport of high-energy electrons in our bodies, comparable to the copper wires in an electric car.
NAD+ is essential for three main functions in the cell: converting fuel into ATP (energy), building cellular components, and repairing damage. Dr Brenner emphasises that while the idea that blood NAD levels universally decline with ageing is sometimes exaggerated, it is undeniably true that specific tissue reserves become disrupted by metabolic stress, disease, and inflammation.
The main scientific insights from the conversation are:
- Inflammation as a Major Energy Consumer: Both acute infections (such as COVID-19) and chronic conditions (such as obesity and heart failure) activate enzymes such as PARPs. These enzymes 'consume' NAD+ to repair damage and stimulate the immune system, which can lead to a cellular deficiency.
- NR as a Superior Precursor: Dr Brenner explains why swallowing NAD+ or NMN directly is less efficient. Because of phosphate groups, these molecules cannot enter the cell directly. NR can do so and is the most clinically tested and safe method for increasing NAD levels in tissues.
- Synergy with Movement: NR supplementation works best in combination with exercise. Where exercise ensures the creation of new mitochondria, NR provides the necessary fuel (NAD+) to keep these engines running optimally.
- New Applications: There is promising evidence for the use of NR in peripheral arterial disease (intermittent claudication), with patients able to walk significantly greater distances following supplementation. It is also used in the sports world (including by the New England Patriots) for faster recovery after physical exertion.
- Sourcing and Safety: The source of the supplement is crucial. Dr Brenner advises using only clinically tested and certified forms of NR (such as Niagen) to guarantee purity and effectiveness.
The video concludes that supporting the NAD system, especially during periods of stress or ageing, is a powerful strategy for building resilience, reducing inflammation and improving the body's overall recovery capacity.
Harvard professor reveals age-rejuvenating science to look younger and feel younger with David Sinclair
Harvard professor reveals the science of rejuvenation
In this episode of Moonshots, Dr David Sinclair discusses how we have shifted from merely 'slowing down' ageing to actually 'resetting' the biological clock. Sinclair argues that ageing is essentially a loss of epigenetic information — comparable to software corruption — and that his lab has found a way to activate the 'back-up copy' of youth in our cells.
The most spectacular breakthrough being discussed is the use of Yamanaka factors (OSK genes) to reprogram tissues. Sinclair's lab has already succeeded in curing blindness in mice and monkeys by rejuvenating the optic nerve. The aim is to start the first clinical trials in humans in 2026 to tackle blindness caused by glaucoma or strokes in the eye.
Important insights into the future of life extension are:
- Epigenetic Reprogramming: By temporarily switching on specific genes that are normally only active in embryos, cells can be reset to a younger state. This process has proved to be safe and repeatable in animal models.
- The role of AI: Sinclair uses AI to virtually screen trillions of molecules. What used to take years now happens in months. This has led to the discovery of cocktails of molecules that have the same rejuvenation effect as gene therapy, but in the form of a simple, inexpensive pill.
- Longevity Escape Velocity: The prediction is that around 2030 we will reach a point where, for every year you live, science adds more than a year to your life expectancy.
- Economic Impact: Adding just one extra healthy life year to the population would generate tens of trillions of dollars in value for the global economy through lower healthcare costs and increased productivity.
Alongside his vision for the future, Sinclair also shares his personal health-preservation protocol, which includes a plant-based diet, intermittent fasting, strength training, sauna use and supplements such as NMN and resveratrol to activate sirtuins (longevity enzymes). He emphasises that maintaining muscle mass and stable blood sugar levels are crucial to bridge the gap until true rejuvenation therapies become available.
The general message is one of immense hope: the first person to reach 150 years of age has probably already been born, and within 10 years a 'rejuvenation cure' in pill form could be a reality.