Researchers have discovered a unique RNA strain that occurs only in primates and accelerates the ageing process. This RNA does not produce proteins, but does regulate important processes in our cells. As we age, the functioning of this RNA changes, causing cells to age faster.
This RNA strand, called LINC01021, is present in multiple tissues and increases as we get older. Experiments with human cells show that high levels of LINC01021 lead to more cells entering a stage of old age, also known as senescence. Conversely, less of this RNA actually results in fewer aged cells.
Further research has shown that LINC01021 suppresses a protein that normally protects against the effects of ageing. This triggers a chain reaction that ultimately accelerates the ageing process. Tests on genetically modified mice confirmed that this RNA influences physical frailty and increased inflammation.
This research shows that certain ageing processes are unique to primates, which is important when developing treatments. Understanding these RNAs could potentially contribute to strategies for healthier ageing.
Source: Josh Conway
