As we age, damaged cells sometimes accumulate in our bodies. These so-called senescent cells disrupt the functioning of surrounding healthy cells. Although they often make up only a small fraction of the total, they can affect the surrounding tissue and thus contribute to all kinds of age-related problems.
Research is actively being conducted into how best to tackle these senescent cells. Two methods stand out. The first focuses on destroying these cells using special medicines called senolytica. The second method aims precisely to prevent these cells from emitting harmful signals, using senomorphics. These medicines inhibit the negative influence without killing the cells.
It turns out that senomorphics, such as the drug rapamycin, are an affordable and promising option. Unfortunately, these agents receive less attention within the medical world because there is little profit to be made and research therefore proceeds with difficulty. The use of these drugs does require daily intake, unlike senolytics which are taken occasionally.
Scientists are still fiercely debating the best approach, because removing these cells can also carry risks. Sometimes, senescent cells actually help to support tissues that are already damaged. Therefore, further studies are needed to ensure safe use, especially for conditions that are common in the elderly.
These developments are important, because reducing harmful ageing processes contributes to healthy ageing and a better quality of life in later life.
Source: Reason
