Scientists have discovered a new method to apply senolytics in lower doses. Senolytics are medicines that clear out old and damaged cells, which can help with healthy ageing. One of the better-known agents, navitoclax, previously had many side effects, particularly on platelets. As a result, this medicine was used less frequently.
The new combination makes it possible to administer navitoclax at a much lower dose, which will likely reduce side effects. This could make the drug interesting again for further research and potential use. Even so, for the time being, attention will mainly remain focused on other senolytics such as dasatinib and quercetin, which have appeared safe and effective for longer.
Senolytics target senescence, a process in which cells age and no longer function properly. These cells can cause inflammation and hinder tissue repair. The removal of these cells can contribute to the maintenance of health and vitality in older age.
This new research direction offers hope for better and safer treatments that contribute to a long and healthy life. It is important that there are more studies to confirm the long-term effects and safety.
Source: Reason
