Researchers have discovered that a key fatty acid in the membranes of mitochondria decreases with age. Mitochondria are the powerhouses of our cells and play a crucial role in the ageing process. If these powerhouses function less effectively, this can affect health and the ageing process.
In the new research, scientists focused on a substance that helps with the production of phosphatidylcholine, the most abundant fatty acid in mitochondrial membranes. Phosphatidylcholine is important because it ensures the correct fluidity of the membrane, enabling mitochondria to function properly. In older animals, and potentially humans too, the level of this substance decreases, which can cause mitochondrial damage.
The researchers studied nematode worms that, despite having poorer functioning mitochondria, still lived longer than normal. Their research showed that maintaining phosphatidylcholine levels helps mitochondria to function better. A dietary supplement containing choline, a building block for phosphatidylcholine, even caused damaged mitochondria in laboratory cells to improve again.
These findings are also consistent with older data on humans. Older men and post-menopausal women show a decrease in phosphatidylcholine in their blood. This can contribute to poorer mitochondrial function and therefore influence the ageing process. This research offers hope that supplementing certain fatty acids in the diet can help maintain cellular energy production as we age.
These insights are valuable for anyone who wants to age healthily, as they point to new possibilities for slowing down the ageing process at a cellular level.
Source: Arkadi Mazin
