As we age, the intervertebral discs in the back can wear down, causing pain and stiffness. Researchers are focusing on combating old, damaged cells that accelerate this process. These cells, known as senescent cells, cause inflammation that further damages the tissue.
New research involving mice shows that a combination of the substances dasatinib and quercetin works better than navitoclax, another drug that targets these harmful cells. These medicines help to clear senescent cells, allowing the tissue to repair itself better and preserving the functions of the intervertebral discs.
Dasatinib and quercetin originally come from cancer research, but also appear to be safe and affordable for broader applications. This makes them interesting for further research, especially for older people who want to suffer less from back problems due to ageing.
Tackling senescent cells is a promising step to support healthy ageing. By combating tissue ageing, older people may potentially remain mobile and pain-free for longer.
Source: Reason
