Researchers are making increasing strides in understanding ageing and how this process can be influenced. A recent focal point is research into a special variant of the BPIFB4 gene. This genetic variant occurs more frequently in people who live longer than average. It turns out that this variant protects the heart and blood vessels and reduces inflammation associated with ageing.
Additionally, progress is being made in the repair of ageing tissues. Scientists have created special cells from stem cells that can repair damaged retinas in the eye in mice. This is important because retinal damage is a cause of age-related blindness and other eye problems that are common in older people.
Another important topic in ageing research is the role of so-called ‘senescent cells’. These are old cells that no longer function properly and can cause damage in the body. Research shows that variants of the SIRT6 protein in centenarians help to reduce these harmful cells. This opens up possibilities to selectively clear out cells that threaten health via medication.
Finally, treatments with existing agents such as dasatinib and quercetin are promising for making the kidneys and potentially other organs younger and healthier again. These substances also clear senescent cells and thus improve the body's functioning.
These developments are relevant because they contribute to living longer and healthier lives in older age, with fewer diseases and disabilities.
Source: Reason
