Researchers have developed a new therapy that combines senolytics with stem cells to repair damaged tissue. Senolytics are substances that clear out aged and harmful cells, also known as senescent cells. Stem cells can help regenerate tissue. Together, they appear to work better than individually.
The study focused on mice with artificially induced organ damage, for example caused by toxins or chemotherapy. The combination improved recovery and reduced inflammatory responses. Mice had energy for longer and survived the treatment more often. This is promising, because senescent cells can inhibit the ability of stem cells to heal.
The stem cells used, mesenchymal stem cells, are normally not as healing as expected. That is because there are many senescent cells in ageing tissue. By first tackling those harmful cells with senolytics, the body gets more room for recovery. This idea can improve the effectiveness of stem cell therapies.
Although the results in mice with artificial damage are promising, it is still uncertain how this works in naturally aged humans. More research is needed before this can also be applied to older people. Nevertheless, this approach offers a new perspective on promoting better health at an advanced age.
This combination of methods may potentially contribute to a more active and healthier life as we grow older.
Source: Arkadi Mazin
