As they age, many people lose muscle mass and strength. This not only leads to reduced mobility, but also affects the body's metabolic process. After all, muscles do not just provide strength; they also play a role in regulating important functions such as insulin sensitivity.
Muscle loss at an older age is caused by several factors. For instance, nerve signals between nerves and muscle fibres weaken, which is necessary for muscle adaptation. In addition, muscle stem cells become less active, leading to a decrease in muscle repair and growth. Furthermore, the reduction of the protein NOX4 plays a role in this process.
NOX4 is important for the creation of a certain type of ‘active oxygen molecule’ that is produced during muscle use. These molecules signal that muscles need to repair and grow. With ageing, the amount of NOX4 decreases, meaning the repair mechanism does not work properly and muscles do not grow as well after exercise.
This discovery provides more insight into why regular exercise at an older age has less effect on muscle growth. It highlights the importance of stimulating muscle activity and health to slow down decline. Exercise remains essential as ever for healthier ageing and a better metabolism.
Source: Reason
