Researchers continue to search for ways to better understand and combat age-related diseases and the decline caused by ageing. Recent research focuses on improving the measurement of the physical and mental abilities that together make up ‘intrinsic capacity’. This term, coined by the World Health Organization, encompasses movement, senses, mental health and cognitive power, among other things. It remains unclear how these capacities should be measured precisely, but it helps in the development of new therapies for older people.
Furthermore, attention is growing regarding the role of a disturbed acidity in the body, also known as metabolic acidosis. This occurs when the body is insufficiently able to correct for oxygen deficiency in tissues. This process appears to contribute to frailty in the elderly, such as muscle loss, inflammation and decreased immunity. By researching this more thoroughly, scientists hope to find new treatments to reduce age-related decline.
Attention is also paid to the kidneys, which often function less effectively as people age. Chronic kidney disease appears to be strongly linked to the ageing process in kidney cells. Special cells that emit senescence signals can cause inflammation and damage tissue. Some new medicines aimed at clearing away these cells are already in development and show promise for better care for kidney problems in later life.
Another promising development is the stimulation of tissue repair in mammals using genes. In some animals, such as salamanders, limbs can completely regrow. Scientists are investigating how certain genes that promote this process can also be activated in mice. This could eventually lead to new ways to improve human regenerative capacity, which is especially valuable for maintaining mobility in old age.
These studies show that progress is being made in understanding and addressing ageing processes and their consequences. This is important for improving the quality of life in later life.
Source: Reason
