A recent study has shown that the hormone thymulin, produced by the thymus, can help to reduce inflammation that often increases with ageing. This chronic, low-grade inflammation is called inflammaging and contributes to the weakening of the immune system at an older age. The researchers found that thymulin reduces inflammation, particularly in older mice, and improves the effectiveness of cancer treatments.
The thymus plays an important role in the immune system by producing T cells, which help the body fight infections and cancer. As people age, the thymus shrinks and produces fewer hormones such as thymulin. This leads to more inflammatory cells and a less-functioning immune system. By administering thymulin to older mice, the researchers were able to reduce inflammatory responses and slow down tumour growth.
Interestingly, the hormone has no noticeable effect in young mice, suggesting that it can specifically target ageing-related problems. It also appeared that older mice treated with thymulin responded better to cancer immunotherapy. This is a promising discovery for improving medical treatments in older people.
These findings bring closer the possibility of better managing age-related inflammation and thus supporting health in older age. The research highlights the importance of the thymus as a link between ageing, inflammation and disease.
It is a step forward in understanding how we can strengthen the immune system at an older age and thus remain healthy and active for longer.
Source: Anna Drangowska-Way
