Researchers have discovered that increasing the protein sirtuin 6 in liver cells can reverse age-related changes in DNA. The protein affects the structure of the DNA in the cell nucleus, allowing genes to be activated more effectively again. This is important because the way DNA is folded determines which genes are active and how cells function.
As we age, the structure of chromatin, the material in which DNA is packaged, changes. These changes often lead to poorer gene expression, which plays a role in the signs of ageing in cells. By increasing the expression of sirtuin 6, cells regain a younger DNA pattern, leading to healthier cell activity.
This research is part of a broader quest for methods to improve the epigenetic control of DNA. Epigenetics refers to chemical changes to the DNA and proteins that affect how genes are switched on or off without altering the DNA itself. The aim is to influence these changes more safely and effectively for better health in later life.
The findings hold promise for new treatments that can slow down or partially reverse ageing. It is a step closer to maintaining health and vitality in later life by improving cellular functions.
For anyone who wants to age healthily, this is important news, because it shows that ageing processes might not be irreversible.
Source: Reason
