New research in mice shows that removing old, damaged brain cells can improve brain function. In the brain, microglia play an important role as defenders against disease. As they age, some of these microglia can become senescent and start causing inflammation, which can disrupt brain function.
These ageing microglia are referred to as senescent and contribute to the development of neurodegenerative diseases such as Alzheimer's. The research shows that specific treatments, called senolytics, effectively clear out these harmful cells. This ensures a healthier brain structure and can support cognitive functions.
Although promising, the application of senolytic agents in humans is still in its infancy. So far, only a few small clinical trials have been conducted, including in Alzheimer's patients. More research is needed to make these treatments safe and effective for humans.
This research gives hope that in the future new therapies can help to keep the brain healthy for longer. By clearing out ageing immune cells, ageing processes can potentially be slowed down.
It is an important step in understanding how we can prevent brain disorders and age healthily.
Source: Reason
