As we age, certain cells in our body increase that no longer function properly. These so-called senescent cells cause inflammation that is harmful to keeping organs, including the liver, healthy. Researchers discovered that a specific group of senescent immune cells, called macrophages, strongly contributes to liver ageing.
Macrophages are cells that normally help to clear away harmful substances and pathogens. However, when they become senescent, they actually cause chronic inflammation. This long-term inflammation negatively affects the liver and can lead to severe conditions such as fatty liver disease, inflammation, scarring and ultimately liver cancer.
Interestingly, new treatments aimed at clearing these senescent macrophages significantly reduce inflammation and liver problems in mouse trials. This indicates that targeting these specific cells can slow down the liver ageing process and reduce the likelihood of liver disease.
Liver damage due to ageing is common and has major consequences for our health. By better understanding which cells are responsible for this damage, targeted therapeutic strategies can be developed that contribute to better health in older age.
This discovery underlines how tackling senescent cells can help to make ageing healthier and prevent liver diseases.
Source: Reason
