Researchers have discovered that the loss of a key fat molecule in the membranes of mitochondria contributes to the ageing of these cellular power plants. Mitochondria are essential for supplying energy and their decline is seen as a hallmark of the ageing process. The decrease in the fat known as phosphatidylcholine can hinder mitochondrial function, making older cells less energy-efficient.
The study focused on the nematode worm, an organism often used in ageing research. Worms with a genetic predisposition to a long lifespan received particular attention. These specimens had mitochondria that, despite their limitations, deteriorated less than those in normal worms. This coincided with a more stable fat content in the mitochondrial membranes, pointing towards a protective effect.
Furthermore, the scientists showed that supplementing phosphatidylcholine or its building blocks restored mitochondrial structures and reduced stress. In addition to worms, human data were examined. This also revealed that the amount of phosphatidylcholine in the blood decreases with age, especially in women around the menopause. This aligns with the idea that supporting mitochondria through nutrition can contribute to better energy levels at an older age.
The findings are important because they show that the mitochondrial ageing process is not irreversible. By intervening specifically in the composition of the mitochondrial membranes, it may be possible to slow down ageing and thus improve quality of life. This opens up new avenues for healthy lifestyle and nutritional interventions in the elderly.
Source: Arkadi Mazin
