The klotho gene is one of the few genes strongly linked to a longer lifespan. This gene produces a protein that is particularly notable for slowing down the ageing process. Researchers have observed that increased activity of this gene in mice leads to a longer lifespan and better health. Its influence on the brain in particular is attracting a lot of attention.
As people age, brains can deteriorate, which often leads to forgetfulness and other memory problems. According to studies, the klotho protein can contribute to the preservation of brain functions. This possibly happens because the protein protects cells against damage and inflammation that increase with age. Therefore, companies are developing new therapies to use klotho as a remedy against brain ageing.
Work is underway on treatments that activate the klotho gene or introduce the protein into the body. This can be done via special medication containing klotho fragments or via gene therapies, which prompt the body to produce more klotho. The effect of this is currently mainly being investigated in animal trials, but the results are promising.
Although klotho also plays a role in the ageing of other organs such as the kidneys, the focus is now primarily on the brain. The exact mechanism of klotho in the brain is not yet entirely clear. Scientists hope that further research will provide more insight into how the gene can reduce age-related symptoms.
For people who want to age healthily, stimulating the klotho gene can be an important step in slowing down cognitive decline. This makes the klotho protein a promising subject in the fight against brain ageing.
Source: Reason
