Researchers have gained new insights into how spinal vertebra ageing occurs. It turns out that not only cell damage is important, but also changes in so-called epigenetics. Epigenetics concerns how the genetic material in cells is ‘switched on’ or ‘switched off’, without the DNA itself changing. This influences which genes are active and which proteins the cell produces.
As we age, these epigenetic patterns change in a way that can be harmful to the cells of the intervertebral discs. These discs provide shock absorption in our backs. The changes in epigenetics lead to increased ageing and breakdown of the back tissues. This can lead to pain and mobility issues, something that many older people experience.
This study points out that ageing is a complex process in which various mechanisms influence each other. For example, epigenetic changes also affect how cells handle damage and waste products, and can thus accelerate the ageing process. Understanding these processes can help in the development of treatments that improve spinal health.
For people who want to age healthily, it is important to know that ageing at the cellular level can be actively influenced. Thanks to developments in science, better ways to prevent or treat back problems may soon become available.
Source: Reason
