Researchers have discovered that combining two substances, NMN and apigenin, can help to restore muscle function and bone structure in older mice. NMN is a precursor to NAD+, a substance in our cells that is involved in important processes such as energy production and damage repair. Apigenin, a flavonoid found in plants such as chamomile, helps to counteract the loss of NAD+.
As we get older, NAD+ levels in our cells decline due to the increased activity of a specific enzyme. This leads to reduced muscle strength and brittle bones. In the laboratory, researchers showed that the combination of NMN and apigenin could reverse this decline by restoring NAD+ levels. This also improved inflammatory responses and the cell's energy factories, known as mitochondria.
Next, the scientists tested the combination on older mice. As a result, these mice developed stronger muscle tissue and better motor skills than comparable animals without treatment. They also observed a beneficial effect on the gut microbiota, which is important for overall health. The combination proved more effective than using either substance alone.
Although the research is promising, the effects in humans still need to be investigated. Nevertheless, these results offer hopeful leads for treatments that can contribute to healthy ageing by counteracting muscle and bone loss.
These findings are important because they show a new way to reduce age-related problems and thus improve the quality of life in later life.
Source: Josh Conway
