Researchers have developed a new combination of drugs that can kill both senescent cells and cancer cells. As people age, so-called senescent cells accumulate in the body. These cells no longer divide, but release harmful substances that cause inflammation and tissue damage. This process contributes to age-related ailments and increases the risk of cancer.
The scientists combined three existing medicines: dichloroacetate, metformin and navitoclax, in a low dose. This combination, called DMA, proved in trials with mice to tackle both harmful cell types effectively without damaging healthy cells. The treatment even ensured that old mice lived longer and were able to move better.
Navitoclax alone has not yet been approved due to side effects such as a reduction in platelets, but in this combination the dosage is much lower, meaning these problems occur less often. Dichloroacetic acid and metformin have already been used more frequently as anti-ageing and cancer agents because of their effect on energy production in cells.
Research shows that it is possible to specifically target cells with a poor energy metabolism while healthy cells continue to function. This could be a new step in treatments that combat ageing and cancer simultaneously.
For everyone interested in healthy ageing, this development is promising, as it can improve the approach to age-related complaints and diseases.
Source: Josh Conway
