Research into people who reach extreme old age can help us understand why they stay healthy for a long time. Scientists have discovered a gene variant, SIRT6, which is more common in centenarians. This gene helps cells deteriorate less quickly due to ageing. As a result, tissues and organs continue to function properly for longer.
Ageing causes cells to become senescent. This means that they can no longer divide and produce signalling molecules that are harmful to surrounding cells. The SIRT6 variant found in centenarians reduces this effect. As a result, there is less damage in the body as people grow older.
The discovery highlights the importance of new treatments aimed at removing or suppressing senescence. Such therapies, also known as senotherapeutics, could potentially slow down the aging process. This is not just about gene editing, but primarily about actively combating aged cells.
This research offers hope for healthy ageing, as it provides insight into biological processes that enable longevity. By gaining a better understanding of the role of genes such as SIRT6, future therapies can be enhanced. In this way, people remain fit and vital for longer.
Improving health in later life is crucial for a good quality of life.
Source: Reason
