Scientists are making increasingly more discoveries about the molecular processes that influence ageing. A recent breakthrough comes from researchers at the Buck Institute, who focus on understanding old age and age-related diseases.
An important part of this research focuses on coenzyme A, a molecule involved in many reactions in our cells. However, this molecule can also cause unwanted reactions, leading to what is known as ‘carbon stress’. This is similar to oxidative stress, where harmful substances are produced when using oxygen. Carbon stress can damage cells and thus contribute to ageing.
The body has a defence mechanism in the form of sirtuins, enzymes that repair impaired proteins. In the case studied, sirtuin 5 helps regulate the urea cycle process, which breaks down harmful ammonia. This is essential for the healthy functioning of the body, as the accumulation of ammonia can have serious consequences.
The discovery underlines just how important such a small molecular process can be for our health and vitality. By better understanding how sirtuins work, researchers may be able to develop methods to slow down the ageing process and promote healthy ageing.
Source: Buck Institute
