Researchers at the Buck Institute have made an important discovery about a molecule that plays a major role in our metabolism and ageing process. It concerns coenzyme A (CoA), a substance that triggers many reactions in our cells. Although CoA is necessary, its by-products can also cause damage, similar to the well-known phenomenon of oxidative stress.
These harmful by-products cause what scientists call “carbon stress”. This is a form of stress in cells that arises because CoA becomes too active and affects other important proteins. If these proteins do not function properly, it can lead to cell deterioration and contribute to age-related diseases.
Fortunately, our bodies have special proteins called sirtuins that can repair this damage. A specific sirtuin, sirtuin 5, turned out to play a major role in clearing up these effects, especially in processes such as the removal of toxic ammonia from our bodies. This is crucial, because if these waste products are not broken down properly, they can seriously harm our health.
This discovery shows how sophisticated our bodies are at staying healthy, even as we age. It helps scientists better understand how tiny molecular processes influence aging and opens up new avenues for potentially extending a healthy lifespan.
Source: Buck Institute
