Scientists have discovered that the APOE2 variant of the APOE gene helps brain cells to be more resistant to ageing. The research shows that this gene variant reduces DNA damage in brain cells and slows down their ageing process. This may play an important role in maintaining healthy brain function at an older age.
The APOE gene has multiple variants, of which APOE2 and APOE4 are known. APOE4 increases the risk of Alzheimer's disease, whereas APOE2 is associated with a longer lifespan. The gene plays a role in the transport of fats, such as cholesterol, in the body and also in the brain.
This new finding indicates that APOE2 not only influences fat transport, but also directly protects the brain cells themselves. The research was carried out in cell cultures, which means that the effect was studied in a controlled environment. The precise mechanism of APOE2 on the cells remains unclear.
For people who want to age healthily, it is interesting that genetic factors such as APOE2 can slow down the ageing process in the brain. This kind of knowledge helps us to better understand why some people remain healthy for longer and provides insight into potential new health strategies.
Source: Reason
