Researchers have discovered a new way to improve muscle function in ageing animals. They reduced the activity of the ghrelin receptor in mice, a receptor involved in feelings of hunger and energy metabolism. This led to better functioning of the mitochondria, the powerhouses within the muscle cells.
Mitochondria play an important role in supplying energy to muscles. In old age, they often function less well, which can contribute to muscle weakness. By making the ghrelin receptor less active, the scientists saw that mitochondrial function improved and muscle strength consequently increased, without the muscle mass itself growing.
Although this method did not lead to an increase in muscle mass or a longer lifespan in the mice, it offers a new approach to combat age-related muscle weakness, also known as sarcopenia. Until now, there is no medicine that can effectively treat this condition.
For older adults, stimulating good muscle function is important to remain active and independent. Research like this could yield new treatments in the future that improve the quality of life.
Source: Reason
