Chronic kidney disease occurs mainly in older people, but can also affect younger individuals. Scientists investigated the role of ageing cells, known as senescent cells, in the onset and exacerbation of this condition. Senescent cells are cells that no longer divide and can trigger an inflammatory response. This is not problematic at a young age, as the immune system usually clears these cells away.
As we age, the immune system becomes less effective, causing these senescent cells to accumulate in the kidneys. This leads to long-term inflammation and damage to the renal tissue, which is disastrous for kidney function. This process bears many similarities to the natural ageing process of the kidneys, which gives reason to view chronic kidney disease as an accelerated form of kidney ageing.
Researchers are now also looking into new treatments that target these senescent cells, known as senotherapeutics. These medicines can remove the harmful cells or reduce their negative influence. Initial trials with this new approach are already underway, for instance in kidney problems caused by diabetes.
These insights offer hope for better treatments to combat kidney disease in older adults. By intervening at an early stage, the loss of kidney function may be slowed down. This is important for healthy ageing and maintaining a good quality of life in later life.
Source: Reason
