Researchers have discovered a link between a growth hormone substance, FGF21, and the slowing down of wear and tear on the intervertebral discs. This wear and tear, also known as intervertebral disc degeneration, is a major cause of back problems in older adults. In particular, reducing cellular ageing in this area can alleviate symptoms.
FGF21 declines as we get older and plays a role in maintaining muscle strength and cell health. In research with rats, scientists fought the wear and tear by administering FGF21. They saw improvements in the recovery of damaged cells and a decrease in inflammatory responses. This is due to improved functioning of mitophagy, a process that clears away damaged parts of cells.
In addition, FGF21 stimulates the protein SIRT1, which is important for cell renewal and protection against ageing. This protein also helps to kick-start waste removal in cells, thereby improving the health of intervertebral discs. Although the research has mainly been conducted in animal models, it offers hope for future treatments to prevent back pain as people age.
For those striving for healthy ageing, this is relevant because it opens up new possibilities to counteract the effects of ageing in the back and thereby maintain mobility and quality of life for longer.
Source: Josh Conway
