A recent study has discovered a new protein that plays an important role in the ageing process in our cells. This protein, PTCHD4, was virtually unknown in the scientific world until now. It appears to be strongly involved in what we call cellular ageing, or senescence. This is the process in which cells lose their function and cause age-related complaints.
The researchers were able to demonstrate that PTCHD4 increases in various types of cells when they are damaged or age. In mice without this protein, aging occurred more slowly and they lived longer than ordinary mice. Typical symptoms of aging, such as grey hair, were also observed less frequently. In addition, these mice were better protected against lung diseases that often occur in old age, such as pulmonary fibrosis.
Importantly, PTCHD4 does not work via the well-known “Hedgehog pathway” in cells, but via a different signalling molecule, AKT. This molecule plays a role in ageing and inflammation. Due to the absence of PTCHD4, the activity of AKT decreased, which slowed down ageing. This makes PTCHD4 an interesting new target for future treatments that can improve the health of ageing people.
Although this research is promising, it is still at an early stage. More studies are needed to understand how PTCHD4 works precisely and how it can be safely targeted in humans. For anyone wanting to age healthily, understanding such new discoveries can help find better ways to combat ageing and age-related ailments.
Source: Josh Conway
