As we get older, the body accumulates more damaged and ageing cells. These cells are no longer able to divide and produce substances that cause inflammation. Normally, these cells are cleared away by the immune system, but in older people this process becomes less efficient. This can lead to problems in organs such as the kidneys, which begin to function less effectively.
Researchers have discovered that certain immune cells in the kidneys, called macrophages, play an important role in this ageing process. These cells develop a receptor on their surface called P2RX7, which increases as they age. By blocking this receptor with a special medicine, a so-called antagonist, the ageing process of the macrophages can be delayed.
This blockade ensures that fewer harmful inflammatory signals are released and that kidney function improves. This is an important step in combating age-related decline in kidney function. Better kidney function can contribute to a higher quality of life at a later age.
This discovery contributes to the knowledge about how we can age healthily by reducing inflammation and harmful processes in our bodies. It opens up new possibilities for treatments that can reduce age-related complaints.
Source: Reason
